Overarching Principles A Every person with gout should be fully informed about the pathophysiology of the disease, the existence of effective treatments, associated comorbidities and the principles of managing acute attacks and eliminating urate crystals through lifelong lowering of SUA level below a target level. B Every person with gout should receive advice regarding lifestyle:…

Management of acute flare according to the European League Against Rheumatism recommendations. Letters and numbers in parentheses indicate the items of the recommendations presented in the table. Strong P-glycoprotein or CYP3A4 inhibitors are cyclosporin, clarithromycin, ketoconazole and ritonavir. IL, interleukin; NSAID, non-steroidal anti-inflammatory drug; PPI, proton pump inhibitor; ULT, urate-lowering therapy.